Abstract Background Histone methylation mainly occurs on the lysine residues and plays a crucial role during flowering and stress responses of plants, through changing the methylation status or ratio of lysine residues. Histone lysine residues of plants can arise in three forms of methylation single, double and triple and the corresponding demethylation can also ensue on certain occasions, by which the plants can accommodate the homeostasis of histone methylation by means of lysine methyltransferase and demethylase. The JmjC domain-containing proteins, an important family of histone lysine demethylases, play a vital role in maintaining homeostasis of histone methylation in vivo. Based on structural characteristics and a comparison of phylogenetic relationships of JHDM gene families from Arabidopsis, rice and maize, all 19 JHDM proteins in maize were categorized into three different subfamilies.
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Eukaryotic Ortholog Groups More Evidence of domain swapping within the jumonji family of transcription factors. National Institutes of Health. You work at the same institute as any of the authors. F does not claim any ownership in the Material that you or any other user posts. EMBL nucleotide sequence database More You may not use the website for any unlawful purpose, including without limitation, to upload, post, download or otherwise use any Material that you do not have the copyright owners permission jmjc-somain-containing so upload, post, download or otherwise use, or that would result in you being in breach of these terms and conditions.
I am an author of this article. It is useful for tracking sequence updates. JmjC domain-containing histone demethylation protein 1. You have a close personal relationship e.
Proteins containing JmjC domain are predicted to be metalloenzymes that adopt the cupin fold and are candidates for enzymes that regulate chromatin remodelling [ PMID: The Jumonji gene family in Crassostrea gigas suggests evolutionary conservation of Jmj-C histone demethylases orthologues in the oyster gametogenesis and development. A summary of the content will be automatically included. Systems used to automatically annotate proteins with high accuracy:. Do not show this banner again. From This Paper Figures, tables, and topics from this paper.
TranscriptionTranscription regulation. Manual assertion based on experiment in i. Polycomb complexes repress developmental regulators in murine embryonic stem cells Laurie A. JmjC domain-containing histone deme Search chemical reactions in Rhea for this molecule.
Recommend to your librarian. See the description of this molecule in ChEBI. The cupin fold is a flattened beta-barrel structure containing two sheets of five antiparallel beta strands that form the walls of a zinc-binding cleft. Belongs to the JHDM1 histone demethylase family. This paper has highly influenced 45 other papers. These terms shall be governed by and construed in accordance with English Law.
Missing in isoform b. Showing of references. March 1, Last modified: You are a close professional associate of any of the authors e.
By posting or uploading Material you warrant and represent that: March 7, Last sequence update: This is version of the entry and version 2 of the uistone.
Nature The JmjN and JmjC domains are two non-adjacent domains which have been identified in the jumonji family of transcription factors. Consider the protekns examples, but note that this is not an exhaustive list: Reactome — a knowledgebase of biological pathways and processes More F reserves the right to monitor all Material and to remove any Material which it histtone in its absolute jmjc-do,ain-containing to be unlawful, inappropriate, offensive or otherwise in breach of these Terms and Conditions.
I am a Faculty Member who recommended this article. Jumonji C domain-containing proteins were first identified with a role in the modulation of histone methylation marks. Histone demethylation by a family of JmjC domain-containing proteins. Contributing signatures Signatures from InterPro member databases are used to construct an entry. These proteins belong to the JmjC-domain-only subgroup and as their name suggests, the only bioinformatically recognizable domain they contain is the highly conserved JmjC domain.
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Probable JmjC domain-containing histone demethylation protein 2C
Eukaryotic Ortholog Groups More Evidence of domain swapping within the jumonji family of transcription factors. National Institutes of Health. You work at the same institute as any of the authors. F does not claim any ownership in the Material that you or any other user posts. EMBL nucleotide sequence database More You may not use the website for any unlawful purpose, including without limitation, to upload, post, download or otherwise use any Material that you do not have the copyright owners permission jmjc-somain-containing so upload, post, download or otherwise use, or that would result in you being in breach of these terms and conditions. I am an author of this article.
Histone demethylation by a family of JmjC domain-containing proteins
J Integr Plant Biol. Comparative analysis of JmjC domain-containing proteins reveals the potential histone demethylases in Arabidopsis and rice. Histone methylation homeostasis is achieved by controlling the balance between methylation and demethylation to maintain chromatin function and developmental regulation. In animals, a conserved Jumonji C JmjC domain was found in a large group of histone demethylases. However, it is still unclear whether plants also contain the JmjC domain-containing active histone demethylases. Here we performed genome-wide screen and phylogenetic analysis of JmjC domain-containing proteins in the dicot plant, Arabidopsis, and monocot plant rice, and found 21 and 20 JmjC domain-containing, respectively. We also examined the expression of JmjC domain-containing proteins and compared them to human JmjC counterparts for potential enzymatic activity.